Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays

@inproceedings{Lam2011SequenceSI,
  title={Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays},
  author={Kathy N. Lam and Harm van Bakel and Atina G. Cote and Anton van der Ven and Timothy R. Hughes},
  booktitle={Nucleic acids research},
  year={2011}
}
C2H2 zinc fingers (C2H2-ZFs) are the most prevalent type of vertebrate DNA-binding domain, and typically appear in tandem arrays (ZFAs), with sequential C2H2-ZFs each contacting three (or more) sequential bases. C2H2-ZFs can be assembled in a modular fashion, providing one explanation for their remarkable evolutionary success. Given a set of modules with defined three-base specificities, modular assembly also presents a way to construct artificial proteins with specific DNA-binding preferences… CONTINUE READING

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