Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.

@article{Pitonzo2009SequencespecificRA,
  title={Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.},
  author={David Pitonzo and Zhongying Yang and Yoshihiro Matsumura and Arthur E. Johnson and William R. Skach},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 2},
  pages={
          685-98
        }
}
A defining feature of eukaryotic polytopic protein biogenesis involves integration, folding, and packing of hydrophobic transmembrane (TM) segments into the apolar environment of the lipid bilayer. In the endoplasmic reticulum, this process is facilitated by the Sec61 translocon. Here, we use a photocross-linking approach to examine integration intermediates derived from the ATP-binding cassette transporter cystic fibrosis transmembrane conductance regulator (CFTR) and show that the timing of… CONTINUE READING

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