Sequence-specific random coil chemical shifts of intrinsically disordered proteins.

Abstract

Although intrinsically disordered proteins (IDPs) are widespread in nature and play diverse and important roles in biology, they have to date been little characterized structurally. Auspiciously, intensified efforts using NMR spectroscopy have started to uncover the breadth of their conformational landscape. In particular, polypeptide backbone chemical… (More)
DOI: 10.1021/ja105656t

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