Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity

@article{Huston2005SequencespecificEO,
  title={Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity},
  author={J. Huston and R. Hasen{\"o}hrl and F. Boix and P. Gerhardt and R. Schwarting},
  journal={Psychopharmacology},
  year={2005},
  volume={112},
  pages={147-162}
}
There is ample evidence that the neurokinin substance P (SP) can have neurotrophic as well as memory-promoting effects. This paper outlines a recent series of experiments dealing with the effects of SP and its N- and C-terminal fragments on memory, reinforcement, and brain monoamine metabolism. It was shown that SP, when applied peripherally (IP), promotes memory (inhibitory avoidance learning) and is reinforcing (place preference task) at the same dose of 37 nmol/kg. Most important, however… Expand
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