Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5' ends of the viral RNAs.


The enzymatic activity of recombinant influenza virus RNA polymerase is strictly dependent on the addition of a template RNA containing 5' and 3' viral sequences. Here we report the analysis of the binding specificity and physical characterization of the complex by using gel shift, modification interference, and density gradient techniques. The 13S complex… (More)


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