Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis.

@article{Fernandes1998SequencespecificBB,
  title={Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis.},
  author={Mary Fernandes and Nancy P Keller and Thomas H. Adams},
  journal={Molecular microbiology},
  year={1998},
  volume={28 6},
  pages={1355-65}
}
The Aspergillus nidulans aflR gene is found within a 60 kb gene cluster that includes approximately 24 other genes that putatively function in the production of the aflatoxin-related mycotoxin sterigmatocystin. Previous work showed that AflR is a C6 zinc binuclear cluster protein that is conserved across Aspergillus spp. and functions as a pathway-specific transcription factor in activating expression of other cluster genes. In this report, we demonstrate that A. nidulans AflR (AnAflR) is a… CONTINUE READING

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