Sequence-specific DNA binding by Ku autoantigen and its effects on transcription.

Abstract

DNA-dependent protein kinase (DNA-PK) has been implicated in several nuclear processes including transcription, DNA replication, double-stranded DNA break repair, and V(D)J recombination. Linkage of kinase and substrate on DNA in cis is required for efficient phosphorylation. Recruitment of DNA-PK to DNA is by Ku autoantigen, a DNA-end-binding protein… (More)

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Cite this paper

@article{Giffin1996SequencespecificDB, title={Sequence-specific DNA binding by Ku autoantigen and its effects on transcription.}, author={Ward Giffin and Harry Torrance and David J Rodda and Gratien G. Prefontaine and Louise J Pope and Robert J. G. Hach{\'e}}, journal={Nature}, year={1996}, volume={380 6571}, pages={265-8} }