Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.


Ras homologue enriched in brain (Rheb) is a small GTPase that plays an important role in tuberous sclerosis. Here we present the backbone assignments of activated rRheb in complex with the non-hydrolisable GTP analogue GppNHp. These assignments now provide a basis for the analysis of rRheb's interaction with putative effectors in order to further elucidate… (More)
DOI: 10.1007/s12104-007-9030-3