Sequence space and the ongoing expansion of the protein universe

@article{Povolotskaya2010SequenceSA,
  title={Sequence space and the ongoing expansion of the protein universe},
  author={I. Povolotskaya and F. Kondrashov},
  journal={Nature},
  year={2010},
  volume={465},
  pages={922-926}
}
The need to maintain the structural and functional integrity of an evolving protein severely restricts the repertoire of acceptable amino-acid substitutions. However, it is not known whether these restrictions impose a global limit on how far homologous protein sequences can diverge from each other. Here we explore the limits of protein evolution using sequence divergence data. We formulate a computational approach to study the rate of divergence of distant protein sequences and measure this… Expand
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