Sequence-selective binding to DNA of bis(amidinophenoxy)alkanes related to propamidine and pentamidine.

  title={Sequence-selective binding to DNA of bis(amidinophenoxy)alkanes related to propamidine and pentamidine.},
  author={C. Bailly and D. Perrine and J. Lancelot and C. Saturnino and M. Robba and M. Waring},
  journal={The Biochemical journal},
  volume={323 ( Pt 1)},
  • C. Bailly, D. Perrine, +3 authors M. Waring
  • Published 1997
  • Chemistry, Medicine
  • The Biochemical journal
  • The DNA sequences targeted by a complete homologous series of aromatic diamidines have been determined at single-nucleotide resolution via protection from cutting by the endonucleases DNase I, DNase II and micrococcal nuclease. Propamidine, pentamidine and to a lesser extent hexamidine bind selectively to nucleotide sequences composed of at least four consecutive A-T base pairs. In contrast, the binding to DNA of butamidine, heptamidine, octamidine and nonamidine is poorly sequence-selective… CONTINUE READING
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