Corpus ID: 23308962

Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.

@article{Bailly1994SequenceselectiveBT,
  title={Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.},
  author={C. Bailly and I. Donkor and D. Gentle and M. Thornalley and M. Waring},
  journal={Molecular pharmacology},
  year={1994},
  volume={46 2},
  pages={
          313-22
        }
}

C. Bailly, I. Donkor, +2 authors M. Waring

Published 1994

Biology, Medicine

Molecular pharmacology

Footprinting experiments using both DNase I and methidium propyl-EDTA.Fe(II) have been used to investigate the sequence selectivity in binding to DNA of pentamidine and four butamidine analogues active against the Pneumocystis carinii pathogen, which afflicts patients with acquired immunodeficiency syndrome. In common with pentamidine, the butamidine drugs, which contain cis- or trans-1,4-but-2-ene linkers and either bis(amidine) or bis(imidazolidine) terminal groups, bind selectively to DNA… CONTINUE READING

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