Sequence requirements for oligodeoxyribonucleotide inhibitory activity.

  title={Sequence requirements for oligodeoxyribonucleotide inhibitory activity.},
  author={Robert F. Ashman and James A. Goeken and Jennifer Drahos and Petar S. Lenert},
  journal={International immunology},
  volume={17 4},
Inhibitory oligonucleotides (IN-ODN) differing from stimulatory CpG ODN (ST-ODN) by as few as two bases can block ST-ODN-induced proliferation, apoptosis protection and IL-6 secretion in B lymphocytes and the production of IL-12p40 by non-B cells. The main objective of this study was to determine the ODN sequence requirements for inhibition in mice. Starting with a strongly inhibitory 15-mer prototype phosphorothioate sequence, we tested the 60 sequences that differed from the prototype by one… CONTINUE READING
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Sequence preferences for inhibitory oligodeoxyribonucleotides

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