Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex.

@article{Kumar2012SequenceRF,
  title={Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex.},
  author={Ganesan Senthil Kumar and William Chang and Tao Xie and Anand A Patel and Yongbo Zhang and Gang Greg Wang and Gregory David and Ishwar Radhakrishnan},
  journal={Journal of molecular biology},
  year={2012},
  volume={422 4},
  pages={519-31}
}
The transcriptional output at a genomic locus in eukaryotes is determined, in part, by the pattern of histone modifications that are read and interpreted by key effector proteins. The histone deacetylase activity of the evolutionarily conserved Rpd3S/Sin3S complex is crucial for suppressing aberrant transcription from cryptic start sites within intragenic regions of actively transcribed genes. Precise targeting of the complex relies on the chromatin binding activities of the MRG15 (MRG stands… CONTINUE READING
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Structural basis for molecular interactions involving MRG domains : implications in chromatin biology

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