Sequence requirement for transcription in vivo of the human preproenkephalin A gene.


The nucleotide sequence of the 5'-flanking region of the cloned human preproenkephalin A gene, extending to 949 bp upstream of the capping site, has been determined. The preproenkephalin A gene, when joined with an SV40 vector and introduced into COS monkey cells, is efficiently transcribed from its own promoter. To assess the DNA sequence required for… (More)


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