Sequence of the human insulin gene

@article{Bell1980SequenceOT,
  title={Sequence of the human insulin gene},
  author={G. Bell and R. Pictet and W. Rutter and B. Cordell and E. Tischer and H. Goodman},
  journal={Nature},
  year={1980},
  volume={284},
  pages={26-32}
}
The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5′-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences. 
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Analysis of the RNAs containing insulin sequences showed that the insulin introns are excised with precision, and the insulin promoter (cap site) and polyadenylation sites are recognized but are less efficiently employed than the viral late promoter and terminator. Expand
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References

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TLDR
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