Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation.

@article{Stumptner2001SequenceOE,
  title={Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation.},
  author={Cornelia Stumptner and Andrea Fuchsbichler and Manfred Lehner and Kurt Zatloukal and Helmut Denk},
  journal={Journal of hepatology},
  year={2001},
  volume={34 5},
  pages={665-75}
}
BACKGROUND/AIMS Chronic intoxication of mice with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or griseofulvin (GF) results in appearance of Mallory bodies (MBs) and alterations of the keratin cytoskeleton, which are reversible upon drug withdrawal but recur after readministration within 2-3 days. METHODS DDC- or GF-treated and recovered mice were reintoxicated with the original drugs but also colchicine and lumicolchicine. Cytoskeletal alterations of hepatocytes and MB formation were… CONTINUE READING