Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux.

@article{Prichon2008SequenceOC,
  title={Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux.},
  author={Bruno 7 P{\'e}richon and Pierre Bogaerts and Thierry Lambert and Lionel Frangeul and Patrice Courvalin and Marc Galimand},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 7},
  pages={2581-92}
}
Self-transferable IncFI plasmid pIP1206, isolated from an Escherichia coli clinical isolate, carries two new resistance determinants: qepA, which confers resistance to hydrophylic fluoroquinolones by efflux, and rmtB, which specifies a 16S rRNA methylase conferring high-level aminoglycoside resistance. Analysis of the 168,113-bp sequence (51% G+C) revealed that pIP1206 was composed of several subregions separated by copies of insertion sequences. Of 151 open reading frames, 56 (37%) were also… CONTINUE READING