Sequence of centromere separation: differential replication of pericentric heterochromatin in multicentric chromosomes


The dicentric and multicentric chromosomes in L cells and a brain tumor cell line of mouse display only one site of kinetochore formation associated with the ‘active’ centromere. The accessory or ‘inactive’ centromeres show premature separation. These cell lines were treated with 10−6 M 5-bromodeoxyuridine (BrdUrd) followed by anti-BrdUrd antibody to study… (More)
DOI: 10.1007/BF00286919


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