Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

@article{Lemere1996SequenceOD,
  title={Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation},
  author={Cynthia A Lemere and Jan Krzysztof Blusztajn and Hisateru Yamaguchi and Thomas Wisniewski and Dennis J Selkoe},
  journal={Neurobiology of Disease},
  year={1996},
  volume={3},
  pages={16-32}
}
Patients with trisomy 21 [Down syndrome (DS)] progressively develop amyloid beta-protein (A beta) deposits and then other features of Alzheimer's disease (AD), apparently due to increased gene dosage and thus expression of the beta-amyloid precursor protein. Because the neuropathological phenotype in older DS subjects closely resembles that of AD, the examination of DS brains of increasing age provides a unique model of the progression of AD. Here, we characterized the deposition of several A… CONTINUE READING

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