Sequence kernel association test for survival traits.

  title={Sequence kernel association test for survival traits.},
  author={Han Chen and Thomas Lumley and Jennifer Brody and Nancy L Heard-Costa and Caroline Fox and L. Adrienne Cupples and Jos{\'e}e Dupuis},
  journal={Genetic epidemiology},
  volume={38 3},
Rare variant tests have been of great interest in testing genetic associations with diseases and disease-related quantitative traits in recent years. Among these tests, the sequence kernel association test (SKAT) is an omnibus test for effects of rare genetic variants, in a linear or logistic regression framework. It is often described as a variance component test treating the genotypic effects as random. When the linear kernel is used, its test statistic can be expressed as a weighted sum of… CONTINUE READING
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