Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.

@article{Hickman2011SequenceindependentCO,
  title={Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.},
  author={David T. Hickman and Mar{\'i}a Pilar L{\'o}pez-Deber and Dorin Mlaki Ndao and Alberto B Silva and Deepak Nand and Maria Pihlgren and Val{\'e}rie Giriens and Rime Madani and Annie C St-Pierre and Hristina Karastaneva and Luitgard Nagel-Steger and Dieter Willbold and Detlev Riesner and Claude Nicolau and Marc Baldus and A. Kl{\'a}ra Pfeifer and Andreas Muhs},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 16},
  pages={13966-76}
}
Synthetic peptide immunogens that mimic the conformation of a target epitope of pathological relevance offer the possibility to precisely control the immune response specificity. Here, we performed conformational analyses using a panel of peptides in order to investigate the key parameters controlling their conformation upon integration into liposomal bilayers. These revealed that the peptide lipidation pattern, the lipid anchor chain length, and the liposome surface charge all significantly… CONTINUE READING
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