Sequence-function correlations and dynamics of ERG isoforms. ERG8 is the black sheep of the family.

@article{Hoesel2016SequencefunctionCA,
  title={Sequence-function correlations and dynamics of ERG isoforms. ERG8 is the black sheep of the family.},
  author={B Hoesel and Naila Malkani and Bernhard Hochreiter and Jos{\'e} A. F. Bas{\'i}lio and Kalsoom Sughra and Muhammad Saqib Ilyas and Johannes A. Schmid},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1863 2},
  pages={
          205-218
        }
}
The transcription factor ERG is known to have divergent roles. On one hand, it acts as differentiation factor of endothelial cells. On the other hand, it has pathological roles in various cancers. Genomic analyses of the ERG gene show that it gives rise to several isoforms. However, functional differences between these isoforms, representing potential reasons for distinct effects in diverse cell types have not been addressed in detail so far. We set out to investigate the major protein isoforms… CONTINUE READING
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