Sequence diversity of hepatitis C virus: implications for immune control and therapy.

@article{Timm2007SequenceDO,
  title={Sequence diversity of hepatitis C virus: implications for immune control and therapy.},
  author={Joerg Timm and Michael Roggendorf},
  journal={World journal of gastroenterology},
  year={2007},
  volume={13 36},
  pages={4808-17}
}
With approximately 3% of the world's population (170 million people) infected with the hepatitis C virus (HCV), the WHO has declared HCV a global health problem. Upon acute infection about 50%-80% of subjects develop chronic hepatitis with viral persistence being at risk to develop liver cirrhosis and hepatocellular carcinoma. One characteristic of HCV is its enormous sequence diversity, which represents a significant hurdle to the development of both effective vaccines as well as to novel… CONTINUE READING