Sequence diversity in 36 candidate genes for cardiovascular disorders.

  title={Sequence diversity in 36 candidate genes for cardiovascular disorders.},
  author={François Cambien and Odette Poirier and Viviane Nicaud and S M Herrmann and Christine Mallet and Sylvain Ricard and Isabelle Behague and Vincent Hallet and Herv{\'e} Blanc and Val{\'e}rie Loukaci and Joelle Thillet and Alun E. Evans and Jean Bernard Ruidavets and Dominique Arveiler and G{\'e}rald Luc and Laurence Tiret},
  journal={American journal of human genetics},
  volume={65 1},
Two strategies involving whole-genome association studies have been proposed for the identification of genes involved in complex diseases. The first one seeks to characterize all common variants of human genes and to test their association with disease. The second one seeks to develop dense maps of single-nucleotide polymorphisms (SNPs) and to detect susceptibility genes through linkage disequilibrium. We performed a molecular screening of the coding and/or flanking regions of 36 candidate… CONTINUE READING


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