Sequence divergence, functional constraint, and selection in protein evolution.

@article{Fay2003SequenceDF,
  title={Sequence divergence, functional constraint, and selection in protein evolution.},
  author={Justin C. Fay and Chung-I Wu},
  journal={Annual review of genomics and human genetics},
  year={2003},
  volume={4},
  pages={
          213-35
        }
}
  • J. FayChung-I Wu
  • Published 28 November 2003
  • Biology
  • Annual review of genomics and human genetics
The genome sequences of multiple species has enabled functional inferences from comparative genomics. A primary objective is to infer biological functions from the conservation of homologous DNA sequences between species. A second, more difficult, objective is to understand what functional DNA sequences have changed over time and are responsible for species' phenotypic differences. The neutral theory of molecular evolution provides a theoretical framework in which both objectives can be… 

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