Sequence-directed base mispairing in human oncogenes.


The most frequently observed mutations in ras oncogenes in solid human tumors are GC-->AT transitions at the 3' G residue of the GG doublet in codon 12 of these oncogenes. We had shown previously that mutagenesis by thymidine occurred with the same sequence specificity in mammalian cells, in that mutagenesis occurred preferentially at the 3' G of GG… (More)


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