Sequence determinants of a microtubule tip localization signal (MtLS).

@article{Buey2012SequenceDO,
  title={Sequence determinants of a microtubule tip localization signal (MtLS).},
  author={Rub{\'e}n M Buey and Indrani Das Sen and Oliver Kortt and Renu Mohan and David Gfeller and Dmitry B. Veprintsev and Ines Kretzschmar and J{\"o}rg Scheuermann and Dario Neri and Vincent Zoete and Olivier Michielin and Jos{\'e} Mar{\'i}a de Pereda and Anna Akhmanova and Rudolf Volkmer and Michel O. Steinmetz},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 34},
  pages={
          28227-42
        }
}
Microtubule plus-end-tracking proteins (+TIPs) specifically localize to the growing plus-ends of microtubules to regulate microtubule dynamics and functions. A large group of +TIPs contain a short linear motif, SXIP, which is essential for them to bind to end-binding proteins (EBs) and target microtubule ends. The SXIP sequence site thus acts as a widespread microtubule tip localization signal (MtLS). Here we have analyzed the sequence-function relationship of a canonical MtLS. Using synthetic… CONTINUE READING
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