Sequence-dependent separation of trinucleotides by ion-interaction reversed-phase liquid chromatography-A structure-retention study assisted by soft-modelling and molecular dynamics.

Abstract

We studied sequence-dependent retention properties of synthetic 5'-terminal phosphate absent trinucleotides containing adenine, guanine and thymine through reversed-phase liquid chromatography (RPLC) and QSRR modelling. We investigated the influence of separation conditions, namely mobile phase composition (ion interaction agent content, pH and organic… (More)
DOI: 10.1016/j.chroma.2016.09.060

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Cite this paper

@article{Mikulek2016SequencedependentSO, title={Sequence-dependent separation of trinucleotides by ion-interaction reversed-phase liquid chromatography-A structure-retention study assisted by soft-modelling and molecular dynamics.}, author={Kamil Mikul{\'a}{\vs}ek and Kamil S. Jaron and Petr Kulh{\'a}nek and Miroslava Bittov{\'a} and Jan Havli{\vs}}, journal={Journal of chromatography. A}, year={2016}, volume={1469}, pages={88-95} }