Sequence-dependent dynamical instability of the human prion protein: a comparative simulation study.

  • Kourosh Bamdad
  • Published 2017 in Journal of biomolecular structure & dynamics


The present study aimed to explore the most probable regions of the human prion protein backbone for which the initial steps of conformational transitions as a result of intrinsic and extrinsic perturbing factors on the protein structure can be assigned. A total of 0.3-μs molecular dynamics simulations on several analog structures of the protein have been… (More)
DOI: 10.1080/07391102.2017.1375430


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