Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes.

@article{McGregor1999SequencedependentCC,
  title={Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes.},
  author={Tracey D. McGregor and Z Balcarov{\'a} and Y. -G. Qu and Minh Chau Tran and Renata Zaludova and Viktor Brabec and Nicholas Farrell},
  journal={Journal of inorganic biochemistry},
  year={1999},
  volume={77 1-2},
  pages={43-6}
}
In this work, the B-->Z transition of poly(dG-dC).poly(dG-dC) and the B-->A transition of poly(dG).poly(dC) and of calf thymus (CT) DNA fragments modified by antitumor bifunctional polynuclear platinum complexes were investigated by circular dichroism (CD). The transition from the B- to Z-form of DNA was inducible with all three compounds studied, as… CONTINUE READING