Sequence-dependent Synergism between Dichloromethotrexate and 5-Fluorouracil in a Human Colon Carcinoma Cell Line 1

@inproceedings{Sobrero2006SequencedependentSB,
  title={Sequence-dependent Synergism between Dichloromethotrexate and 5-Fluorouracil in a Human Colon Carcinoma Cell Line 1},
  author={Alberto F. Sobrero and Joseph R. Berlino},
  year={2006}
}
Prior to their use in patients with hepatic metastasis of colon cancer, we studied the cell-killing effects of 5-fluorouracil, 5fluoro-2'-deoxyuridine, 3',5'-dichloromethotrexate (DCM), and combinations of these fluoropyrimidines with DCM on a human colon carcinoma cell line (HCT-8). Sequential exposure of these cells to DCM followed by 5-fluorouracil… CONTINUE READING