Sequence-dependent DNA structure. The role of base stacking interactions.

  title={Sequence-dependent DNA structure. The role of base stacking interactions.},
  author={Christopher A. Hunter},
  journal={Journal of molecular biology},
  volume={230 3},
The sequence-dependent structure of DNA is analysed on the basis of the energetics of the base stacking (pi-pi) interactions. The conformational preferences of the ten possible base-pair steps in double-helical DNA have been calculated and compared with experimental data from X-ray fibre diffraction, X-ray crystal structures and gel-running experiments. The calculations account for many features of sequence-dependent DNA structure, including polymorphism in DNA, the lack of polymorphism in RNA… CONTINUE READING

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