Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region.

@article{Huang2007SequenceDO,
  title={Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region.},
  author={Feng-Ting Huang and Kefei Yu and Barbara B Balter and Erlk Selsing and Zeliha Oruc and Ahmed Amine Khamlichi and Chih-lin Hsieh and Michael R. Lieber},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 16},
  pages={
          5921-32
        }
}
The mechanism by which the cytidine deaminase activation-induced deaminase (AID) acts at immunoglobulin heavy-chain class switch regions during mammalian class switch recombination (CSR) remains unclear. R-loops have been proposed as a basis for this targeting. Here, we show that the difference between various forms of the Smu locus that can or cannot undergo CSR correlates well with the locations and detectability of R-loops. The Smu R-loops can initiate hundreds of base pairs upstream of the… CONTINUE READING

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