Sequence context strongly modulates association of polar residues in transmembrane helices.

@article{Dawson2003SequenceCS,
  title={Sequence context strongly modulates association of polar residues in transmembrane helices.},
  author={Jessica P. Dawson and Roman A Melnyk and Charles M. Deber and Donald M. Engelman},
  journal={Journal of molecular biology},
  year={2003},
  volume={331 1},
  pages={255-62}
}
Polar residues are capable of mediating the association of membrane-embedded helices through the formation of side-chain/side-chain inter-helical hydrogen bonds. However, the extent to which native van der Waals packing of the residues surrounding the polar locus can enhance, or interfere with, the interaction of polar residues has not yet been studied. We examined the propensities of four polar residues (aspartic acid, asparagine, glutamic acid, and glutamine) to promote self-association of… CONTINUE READING

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