Sequence context-specific mutagenesis and base excision repair.

  title={Sequence context-specific mutagenesis and base excision repair.},
  author={Katherine A. Donigan and Joann Balazs Sweasy},
  journal={Molecular carcinogenesis},
  volume={48 4},
Base excision repair (BER) is critical for the maintenance of genome stability because it repairs at least 20,000 endogenously generated DNA lesions/cell/d. Several enzymes within the BER pathway exhibit sequence context dependency during the excision and DNA synthesis steps of repair. New evidence is emerging that germ line and tumor-associated variants of enzymes in this repair pathway exhibit sequence context dependence that is different from their ancestral counterparts. We review what is… CONTINUE READING

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