Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope.

@article{Nietfield1995SequenceCA,
  title={Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope.},
  author={W Nietfield and Miroslav Bauer and Mich{\`e}le F{\'e}vrier and Reinhard Maier and Brigitte Holzwarth and Rainer Frank and Bernhard F. Maier and Yves Rivi{\`e}re and Andreas Meyerhans},
  journal={Journal of immunology},
  year={1995},
  volume={154 5},
  pages={
          2189-97
        }
}
Previous studies on the variation of an immunodominant HLA-B27-restricted HIV-1 gag p24 epitope (KRWIIL GLNK, amino acids 263-272) have demonstrated the persistence of variants recognized by CTL. Sequence comparisons of HIV isolates showed that this region is relatively conserved and as a consequence might restrict antigenic variation. To evaluate the possibility of HIV-1 to yield infectious mutants of this epitope that lack the ability to bind to HLA-B27 or escape HLA-B27-restricted CTL… CONTINUE READING

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