Sequence comparison of woodchuck hepatitis virus replicative forms shows conservation of the genome.

@article{Cohen1988SequenceCO,
  title={Sequence comparison of woodchuck hepatitis virus replicative forms shows conservation of the genome.},
  author={Jeffrey I. Cohen and Roger H. Miller and Brian Rosenblum and Katherine J. Denniston and John L. Gerin and Robert H. Purcell},
  journal={Virology},
  year={1988},
  volume={162 1},
  pages={12-20}
}
The complete nucleotide sequence of virion DNA from two isolates of woodchuck hepatitis virus (WHV 7 and WHV 59) was determined along with the sequence of supercoiled DNA from one of those isolates (WHV 7). The sequences of the two WHV isolates were compared with the previously published sequences of two other isolates (WHV 1 and WHV 8). The range of nucleotide sequence variation of the four isolates (1 to 3.5%) was similar to those of HBVs of the same subtype (1.5 to 2%), but less than those… CONTINUE READING