Sequence assembly demystified

  title={Sequence assembly demystified},
  author={Niranjan Nagarajan and Mihai Pop},
  journal={Nature Reviews Genetics},
Advances in sequencing technologies and increased access to sequencing services have led to renewed interest in sequence and genome assembly. Concurrently, new applications for sequencing have emerged, including gene expression analysis, discovery of genomic variants and metagenomics, and each of these has different needs and challenges in terms of assembly. We survey the theoretical foundations that underlie modern assembly and highlight the options and practical trade-offs that need to be… 

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