Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex

@article{Wedaman1996SequenceAS,
  title={Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex},
  author={Karen P. Wedaman and David W. Meyer and Dana J Rashid and Douglas G. Cole and Jonathan M. Scholey},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={132},
  pages={371 - 380}
}
The heterotrimeric kinesin-II holoenzyme purified from sea urchin (Strongylocentrotus purpuratus) eggs is assembled from two heterodimerized kinesin-related motor subunits of known sequence, together with a third, previously uncharacterized 115-kD subunit, SpKAP115. Using monospecific anti-SpKAP115 antibodies we have accomplished the molecular cloning and sequencing of the SpKAP115 subunit. The deduced sequence predicts a globular 95-kD non-motor "accessory" polypeptide rich in alpha-helical… CONTINUE READING

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