Sequence and structure relationships within von Willebrand factor.

  title={Sequence and structure relationships within von Willebrand factor.},
  author={Yan-Feng Zhou and Edward T Eng and Jieqing Zhu and Chafen Lu and Thomas Walz and Timothy A Springer},
  volume={120 2},
In the present study, we re-annotated von Willebrand factor (VWF), assigned its entire sequence to specific modules, and related these modules to structure using electron microscopy (EM). The D domains are assemblies of smaller modules visible as lobes in EM. Modules in the D-domain assemblies include von Willebrand D, 8-cysteine, trypsin inhibitor-like, E or fibronectin type 1-like domains, and a unique D4N module in D4. The D1-D2 prodomain shows 2 large connected assemblies, each containing… CONTINUE READING
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