Sequence and structural analysis of the 5′ noncoding region of hepatitis C virus in patients with chronic infection

@article{Arajo2009SequenceAS,
  title={Sequence and structural analysis of the 5′ noncoding region of hepatitis C virus in patients with chronic infection},
  author={Fl{\'a}vio Marcos Gomes Ara{\'u}jo and Ariane Machado-Lima and Alan M. Durham and Rosa Isabel Sabença Teixeira and Guilherme Corr{\^e}a Oliveira},
  journal={Journal of Medical Virology},
  year={2009},
  volume={81}
}
Hepatitis C virus (HCV), exhibits considerable genetic diversity, but presents a relatively well conserved 5′ noncoding region (5′ NCR) among all genotypes. In this study, the structural features and translational efficiency of the HCV 5′ NCR sequences were analyzed using the programs RNAfold, RNAshapes and RNApdist and with a bicistronic dual luciferase expression system, respectively. RNA structure prediction software indicated that base substitutions will alter potentially the 5′ NCR… 
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TLDR
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