Sequence and structural analysis of BTB domain proteins

  title={Sequence and structural analysis of BTB domain proteins},
  author={Peter J Stogios and Gregory S Downs and Jimmy JS Jauhal and Sukhjeen K Nandra and Gilbert G. Priv{\'e}},
  journal={Genome Biology},
  pages={R82 - R82}
The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination. Several BTB domain structures have been experimentally determined, revealing a highly conserved core structure. We surveyed the protein architecture, genomic distribution and sequence conservation of BTB domain… CONTINUE READING
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