Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals

@article{Chou1994SequenceAP,
  title={Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals},
  author={Zhi-Fang Chou and Fan Chen and Jeffrey Wilusz},
  journal={Nucleic acids research},
  year={1994},
  volume={22 13},
  pages={2525-31}
}
We have defined the positional and sequence requirements of U-rich downstream elements using a simian virus 40 late polyadenylation signal containing a substituted downstream region. A UUUUU element will significantly increase the efficiency of 3' end processing when placed between 6 and 25 bases downstream from the cleavage site. Positions in this interval closer than 15 bases from the cleavage site, however, were noticeably less efficient. Placement of the UUUUU element between +20 and +25… CONTINUE READING

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