Sequence and organization of the human mitochondrial genome

  title={Sequence and organization of the human mitochondrial genome},
  author={Stephen K. Anderson and A. T. Bankier and Barclay G. Barrell and M. H. L. de Bruijn and A. R. Coulson and Jacques Drouin and Ian C. Eperon and Donald P. Nierlich and B. A. Roe and Frederick Sanger and Peter H. Schreier and A J Smith and Rodger Staden and I. G. Young},
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by… 
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