• Corpus ID: 202704588

Sequence and expression of four coral G protein-coupled receptors distinct from all classifiable members of the rhodopsin famil

  title={Sequence and expression of four coral G protein-coupled receptors distinct from all classifiable members of the rhodopsin famil},
  author={David C. Hayward and David J. Miller and Eldon E. Ball},
Ameasure of the functional importance of G protein-coupled receptors (GPCRs) as signallingmolecules is that over seven hundred have been cloned and identified in the human genome alone. Yet few have been characterized in the lowermetazoan phyla, especially in the phylumCnidaria which iswell positioned phylogenetically for tracing the early evolution of GPCRs owing to their possession of the first-evolved nervous systems.We report here the cloning and characterization of four novel rhodopsin… 

Figures and Tables from this paper

Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the Anthozoa

Differences in expression patterns between Acropora and Nematostella largely reflect fundamental differences in developmental processes, underscoring the diversity of mechanisms within the anthozoan Sub-Class Hexacorallia (Zoantharia).

Current Understanding of the Circadian Clock Within Cnidaria

The genes that form this molecular clock and drive biological rhythms in well-characterized genetic systems such as Drosophila and mouse are highly conserved in cnidarians and, like these model systems, display diel cycles in transcription levels.

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

This study represents the first overall map of the GPCR sequences in a single mammalian genome and shows several common structural features indicating that the human GPCRs in the GRAFS families share a common ancestor.

The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes

The results show that the main families in the human genome, Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin, arose before the split of nematodes from the chordate lineage.

The GRAFS classification system of G-protein coupled receptors in comparative perspective.

Molecular evolution of integrins: genes encoding integrin beta subunits from a coral and a sponge.

CDNAs encoding integrin beta subunits from a coral and a sponge are identified and sequenced, indicating that these proteins existed in the earliest stages of metazoan evolution.

A new G protein‐coupled receptor from a primitive metazoan shows homology with vertebrate aminergic receptors and displays constitutive activity in mammalian cells

A full‐length cDNA encoding a polypeptide with typical G protein‐coupled receptor (GPCR) characteristics and which displayed a significant degree of sequence similarity to biogenic amine receptors, particularly dopamine and adrenergic receptors is obtained.

Cloning of a novel G-protein-coupled receptor from the sea anemone nervous system.

The cloning and analysis of genomic and cDNA copies of a gene from sea anemones that encodes a new member of the G-protein-coupled receptor family shows similarity to previously described receptors for biogenic amines, as well as a variety of small molecule agonists and peptides, although the ligand is unable to be determined.

The evolution of nuclear receptors: evidence from the coral Acropora.

Phylogenetic analyses indicate that most, and possibly all, presently identified cnidarian NRs are members of NR subfamily 2, suggesting that the common ancestor of all known nuclear receptors most resembled members of this subfamily.

Molecular tinkering of G protein‐coupled receptors: an evolutionary success

Indirect studies have led to a useful model of a common ‘central core’, composed of seven transmembrane helical domains, and its structural modifications during activation of G protein‐coupled receptors.