Sequence and expression of a novel GABAA receptor alpha subunit.

  title={Sequence and expression of a novel GABAA receptor alpha subunit.},
  author={Sanie Ymer and Andreas Draguhn and Martin K{\"o}hler and Peter R. Schofield and P. H. Seeburg},
  journal={FEBS letters},
  volume={258 1},
Cloned cDNA encoding the bovine alpha 4 subunit of the GABAA receptor has been isolated. The predicted 51 amino acid long mature protein contains an exceptionally long intracellular domain and shares 53-56% sequence similarity to the previously characterized alpha 1, alpha 2 and alpha 3 subunits. Co-expression of alpha 4 and beta 1 in Xenopus oocytes resulted in the formation of GABA-gated chloride channels with expected pharmacology, although no benzodiazepine potentiation was observed… CONTINUE READING

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