Sequence and expression of a metabotropic glutamate receptor

@article{Masu1991SequenceAE,
  title={Sequence and expression of a metabotropic glutamate receptor},
  author={Masayuki Masu and Yasuto Tanabe and Kunihiro Tsuchida and Ryuichi Shigemoto and Shigetada Nakanishi},
  journal={Nature},
  year={1991},
  volume={349},
  pages={760-765}
}
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2−3 and in cerebellar Purkinje cells… Expand
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