Sequence and diversity of bovine T-cell receptor β-chain genes

  title={Sequence and diversity of bovine T-cell receptor β-chain genes},
  author={Atsuko Tanaka and Naotaka Ishiguro and Morikazu Shinagawa},
The nucleotide sequences of 38 T-cell receptor (Tcr) β-chain cDNA clones which were isolated from a cDNA library (2 × 106 plaques) constructed from bovine peripheral blood lymphocytes were determined. Of 38 cDNA clones, 22 were rearranged and contained the functional variable (V) gene segments. These clones were tentatively divided into nine Tcrb-V gene families which correspond to the human Tcrb-V family. Among them, a Tcrb-V12 gene segment was isolated from 9 out of 22 clones, suggesting that… CONTINUE READING