Sequence and diversity of DRB genes of Aotus nancymaae, a primate model for human malaria parasites

@article{NinoVasquez2000SequenceAD,
  title={Sequence and diversity of DRB genes of Aotus nancymaae, a primate model for human malaria parasites},
  author={J. Javier Nino-Vasquez and Denise Vogel and Ra{\'u}l Rodr{\'i}guez and Alberto Moreno and Manuel Elkin Patarroyo and Gerd Pluschke and Claudia A. Daubenberger},
  journal={Immunogenetics},
  year={2000},
  volume={51},
  pages={219-230}
}
Abstract The New World primate Aotus nancymaae is susceptible to infection with the human malaria parasite Plasmodium falciparum and Plasmodium vivax and has therefore been recommended by the World Health Organization as a model for evaluation of malaria vaccine candidates. We present here a first step in the molecular characterization of the major histocompatibility complex (MHC) class II DRB genes of Aotus nancymaae (owl monkey or night monkey) by nucleotide sequence analysis of the… 

Sequence and expression of MHC-DPB1 molecules of the New World monkey Aotus nancymaae, a primate model for Plasmodium falciparum

TLDR
The nucleotide sequences of exon 2 and 3 of MHC-DPB1 genes are presented and no evidence could be found for the conservation of allelic lineages pre-dating the divergence of Old and New World monkeys.

Sequence and diversity of MHC DQA and DQB genes of the owl monkey Aotus nancymaae

TLDR
The results fully support the use of Aotus monkeys as an animal model for evaluation of future subunit vaccine candidates, and essential amino acid residues contributing to MHC DQ peptide binding pockets number 1 and 4 are conserved or semi-conserved between HLA-DQ and Aona-D Q molecules, indicating a capacity to bind similar peptide repertoires.

Characterising a Microsatellite for DRB Typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)

Non-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune

Sequence variability analysis on major histocompatibilitycomplex class II DRB alleles in three felines

TLDR
Results displayed a more close relationship between leopard and tiger; however, clouded leopard has a comparatively distant relationship form the other two; and MEGA neighbor joining and PAUP maximum parsimony methods were used to reconstruct phylogenetic trees among species.

Sequence variation and gene duplication at the MHC DRB loci of the spotted seal Phoca largha.

TLDR
High level of spotted seal MHC-DRB polymorphism revealed in the present study has not been reported for the Phocidae and could be a consequence of the small spotted seal population adapting to the Bohai Sea, which probably has a relatively high level of pathogens.

Identifying and structurally characterizing CD1b in Aotus nancymaae owl monkeys

This study reports the molecular characterization and tissue expression of the non-human Aotus nancymaae primate CD1b isoform in the search for an experimental animal model to be used in evaluating

Structural and functional characterisation of the Toll like receptor 9 of Aotus nancymaae, a non-human primate model for malaria vaccine development

TLDR
The high level of sequence conservation of Aona-TLR-9 reinforces the suitability of A. nancymaae as animal model for malaria subunit vaccine development and selects between different formulations before conducting expensive human clinical trials.

Sequence variation and gene duplication at MHC DQB loci of baiji (Lipotes vexillifer), a Chinese river dolphin.

TLDR
The high level of baijin MHC polymorphism revealed in the present study has not been reported in other cetaceans and could be a consequence of the small baiji population adapting to freshwater with a relatively high levelof pathogens.

Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae)

TLDR
High-throughput sequencing is used to characterize polymorphism in four Class II DR and DQ exons for the first time in capuchin species, and phylogenetic analyses reveal that platyrrhine DQA sequences form a monophyletic group to the exclusion of all Catarrhini sequences examined.
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