Sequence and developmental expression of amphioxus AmphiNk2–1: insights into the evolutionary origin of the vertebrate thyroid gland and forebrain

@article{Venkatesh1999SequenceAD,
  title={Sequence and developmental expression of amphioxus AmphiNk2–1: insights into the evolutionary origin of the vertebrate thyroid gland and forebrain},
  author={Tyamagondlu V. Venkatesh and Nicholas D. Holland and Linda Z Holland and Ming-Tsan Su and Rolf Bodmer},
  journal={Development Genes and Evolution},
  year={1999},
  volume={209},
  pages={254-259}
}
 We characterized an amphioxus NK-2 homeobox gene (AmphiNk2–1), a homologue of vertebrate Nkx2–1, which is involved in the development of the central nervous system and thyroid gland. At the early neurula stage of amphioxus, AmphiNk2–1 expression is first detected medially in the neural plate. By the mid-neurula stage, expression is localized ventrally in the nerve cord and also begins in the endoderm. During the late neurula stage, the ventral neural expression becomes transiently segmented… CONTINUE READING

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